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Based on the Agilent genomic chip's comparative genomic hybridization technology, aCGH (array-based Comparative Genomic Hybridization) enables researchers to quickly locate changes in chromosome-level deletions and amplifications across the genome. Agilent aCGH's probes cover the entire genome and are distributed approximately the same across gene regions (intron regions, exon regions), intergenic regions, and subtelomere regions (excluding repeats) that are important for disease research. It has the advantages of high sensitivity, high accuracy and high resolution, and it is also the most accurate and economical technical method for conducting CNV research in the whole genome.
Genome-wide resequencing is the resequencing of species with known reference genomes, or individuals with a specific phenotype or disease. By comparing with reference genomes, individuals can obtain genome-wide mutation information, including sequence variations And structural variation. It has applications in many aspects such as human disease research and animal and plant genetics breeding.
Whole exome sequencing refers to the use of Agilent's efficient capture probe to hybridize and enrich the DNA sequence of the exon region, followed by high-throughput sequencing, which can economically and efficiently detect mutations in the coding region. Only the exome region is sequenced. This region accounts for about 1% of the genome. High-depth sequencing can be performed to find low-frequency and rare mutations, which is an important technical method for human disease research.
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